David Cram 教授
澳大利亚莫那什大学微生物学博士，前澳大利亚莫纳什大学生殖学系和遗传学系系主任，与其研究小组孕育出了全球第三例试管婴儿，干细胞领域专家。Cram 教授是国际知名的生殖遗传学与辅助生殖分子诊断专家，在胚胎植入前遗传学检测（PGT/PGD）、辅助生殖遗传学、无创产前检测（NIPT）及新一代测序技术在生殖医学中的临床应用领域深耕三十余年，是该领域早期技术体系建立与持续演进的重要推动者之一。
个人经历如下：
Monash IVF植入前遗传学中心主任（1998—2008 年）
贝瑞和康生物，中国 A 股上市公司首席科学家（2013—2021 年）
国际植入前遗传学诊断学会（International Society for Preimplantation Genetic Diagnosis，ISPGD）主席（2020—2021 年）
入选 2014 年中国国家“千人计划”高端外国专家项目，享受中国国务院政府特殊津贴
在国际顶级学术期刊发表经同行评议的研究论文 150 余篇，影响因子超过800，被引用次数超4000余次
著名出版物（有但不仅限于）：
1. Cram DS#, Sherf, BA, Libby RT, Mattaliano RJ, Ramachandran KL, Reeve JN. Structure and expression of the genes, mcrBDCGA, which encode the subunits of component C of methyl coenzyme M reductase in Methanococcus vannielii. Proceedings of the National Academy of Sciences USA, 1987; 84:3992-3996.
2. Cram DS#, Fisicaro N, Coppel RL, Whittingham S, Harrison LC. Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the U1 ribonucleoprotein complex. Journal of Immunology, 1990; 145:630-635.
3. Cram DS#, Song B, Trounson AO. Genotyping of Rhesus SCNT pluripotent stem cell lines. Nature, 2007; 450:E12-14.
4. Wang L, Cram DS#, Shen J, Wang X, Zhang J, Song Z, Xu G, Li N, Fan J, Wang S, Luo Y, Wang J, Yu L, Liu J, Yao Y. Validation of copy number variation sequencing for detecting chromosome imbalances in preimplantation embryos. Biology of Reproduction, 2014; 91:37.
5. Cram DS#, Leigh D, Handyside A, Rechitsky L, Xu K, Harton G, Rubio C, Fragouli E, Kahraman S, Forman E, Katz-Jaffe M, Tempest H, THornhill A, Strom C, Escudero T, Qiao J, Munne S, SimpsonJL, Kuliev A. PGDIS position statement on the transfer of mosaic embryos 2019. Reproductive BioMedicine Online, 2019:39 Suppl 1:e1-e4.
6. Katz-Jaffe GM, Mantzaris D, Cram DS#. DNA identification of fetal cells in cervical mucus: potential for non-invasive prenatal diagnosis. British Journal of Obstetrics and Gynaecology, 2005; 112:595-600.
7. Niclis J, Trounson AO, Dottori M, Ellisdon A, Bottomley S, Verlinsky Y, Cram DS#. Human embryonic stem cell models of Huntington’s Disease. Reproductive Biomedicine Online, 2009; 19:106-113.
8. Lyrawati D, Trounson A, Cram DS#. Expression of GFP in the mitochondrial compartment using DQAsome-mediated delivery of an artificial mini-mitochondrial genome. Pharmaceutical Research, 2011; 28:2848-2862.
9. Niclis JC, Pinar A, Haynes JN, Alsanie W, Jenny R, Dottori M, Cram DS#. Characterization of forebrain neurons from late-onset Huntington’s Disease human embryonic stem cell lines. Frontiers of Cell Neuroscience, 2013; 7:37.
10. Liang D, Peng Y, Lv W, Deng L, Zhang Y, Li H, Yang P, Zhang J, Song Z, Xu G, Cram DS#, Wu L. Copy number variation sequencing for comprehensive diagnosis of human chromosome disease syndromes. Journal of Molecular Diagnosis, 2014; 16:519-526.
11. Song Y, Huang S, Zhou X, Jiang Y, Qi Q, Bian X, Zhang J, Yan Y, Cram DS#, Liu J. Non-invasive prenatal testing for fetal aneuploidies in the first trimester of pregnancy. Ultrasound in Obstetrics and Gynecology, 2015; 45:55-60.
12. Lv W, Wei X, Guo R, Liu Q, Zheng Y, Chang J, Bai T, Li H, Zhang J, Song Z, Cram DS#, Liang D, Wu L. Non-invasive prenatal testing for Wilson Disease using circulating Single Molecule Amplification and Re-sequencing Technology (cSMART). Clinical Chemistry, 2015; 61:172-181.
13. Fan J, Wang L, Wang H, Ma M, Wang S, Liu Z, Xu G, Zhang J, Cram DS#, Yao Y. The clinical utility of next generation sequencing for identifying chromosome disease syndromes in human embryos. Reproductive Biomedicine Online, 2015; 31:62-70.
14. Li N, Wang L, Wang H, Ma M, Wang X. Li Y, Wang S, Zhang W, Zhang J, Cram DS#, Yao Y. The performance of whole genome amplification methods and next generation sequencing for pre-implantation genetic diagnosis of chromosomal abnormalities. Journal of Genetics and Genomics, 2015; 42:151-159.
15. Zhang S, Xia B, Jiang H, Wang L, Xu R, Shi Y, Zhang J, Xu M, Cram DS#, Ma S. Comprehensive profiling of oncogenic mutations in non small cell lung carcinoma using single molecule amplification and re-sequencing technology. Oncotarget, 2016; 7: 50477-50489.
16. Han M, Li Z, Wang W, Huang S, Lu Y, Gao Z, Wang L, Kang D, Li L, Xu M, Cram DS#, Dai P. Performance of a quantitative assay for noninvasive prenatal diagnosis of autosomal recessive hearing loss caused by GJB2 and SLC26A4 mutations. Genetics in Medicine, 2017; 19:1306-1316.
17. Wang J, Chen L, Zhou C, Wang L, Xie H, Xiao Y, Zhu H, Hu T, Zhang Z, Zhu Q, liu Z, Liu S, Wang He, Xu M, Ren Z, Yu F, Cram DS#, Liu H. Prospective chromosome analysis of 3429 amniocentesis samples in China using copy number variation sequencing. American Journal of Obstetrics and Gynecology, 2018; 219:287.e1-287.e18.
18. Wang Z, Cheng G, Han X, Mu X, Zhang Y, Cui D, Liu C, Zhang L, Fan Z, Ma L, Di J, Cram DS#, Shi Y, Liu D. Application of single molecule amplification and re-sequencing technology for broad surveillance of oncogenic mutations in plasma from patients with advanced lung adenocarcinoma. Journal of Molecular Diagnostics, 2017; 19:169-181.
19. Xu L, Mao A, Zhang J, Liu H, Gui B, Choy KW, Huang H, Yu Q, Zhang X, Chen M, Lin N, Chen L, Han J, Wang Y, Zhang M, Li X, He D, Lin Y, Zhang J, Cram DS#, Cao H. Long-molecule sequencing: A new approach for identification of clinically significant DNA variants in alpha and beta-thalassemia carriers. Journal of Molecular Diagnostics, 2020; 22:1087-1095.
20. Liang Q, Gu W, Chen P, Li Y, Liu Y, Tian M, Zhou Q, Qi H, Zhang Y, He J, Li Q, Qin L, Tang J, Teng Y, Zhou Y, Huang S, Lu Z, Xu M, Cram DS#, Wu L. A more universal approach to comprehensive analysis of thalassemia alleles (CATSA). Journal of Molecular Diagnostics, 2021, 23:448-457.
21. Cheng Y, Yu Q, Ma M, Wang H, Tian S, Zhang W, Zhang J, Liu Y, Pan X, Yang Q, Liang H, Wang Li, Leigh D, Cram DS#, Yao Y. Variant haplophasing by long read sequencing: a new approach for PGT workups. Fertility and Sterility, 2021,116:774-783.
22. Shi P, Wang C, Liang H, Zhu X, Wang X, Ning Y, Leigh D, Cram DS#, Kong X. The hidden causes of pregnancy loss: a closer look. Journal of Translational Medicine, 2025, 23:656.
23. Shi P, Liang H, Hou Y, Chen D, Ren H, Wang C, Xia Y, Zhang D, Leigh D, Cram DS, Kong X. The uncertainty of copy number variants: pregnancy decisions and clinical follow up. American Journal of Obstetrics and Gynecology 2023, 229: 170.e1-170.e8.